Kinin levels in the peripheral venous blood of patients with severe vasomotor dumping before and after revisional surgery

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Abstract
The kinin activity in peripheral venous blood was estimated before and after jejunal interposition in 17 patients with severe vasomotor dumping. In each case the kinin activity was assayed both under fasting conditions and after the oral administration of a liquid hypertonic glucose meal (100 g). No significant difference in the preoperative fasting kinin values was found between patients who were improved of their symptoms (11 cases) as distinct from those who did not derive any benefit from jejunal interposition (6 cases). However, in patients who obtained relief after revisional surgery, the kinin level after glucose administration (56.15k ± 11.19 nglml) was significantly higher (P<0.01) than the release obtained in patients who were not improved by surgery (3.65 ± 2.33 nglml). Furthermore, the kinin release was reduced to near normal levels on re-challenge with glucose 3 months after jejunal interposition in patients who were cured or improved of their symptoms.
Funding Information
  • Wellcome Trust
  • Medical Research Committee of the Mersey Regional Health Authority