Conditions of phasic impairment of avoidance responding during bilateral spreading depression.

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Abstract
Recorded the steady potential from the motor cortex of 17 male hooded rats during active avoidance responses. Slow potential waves accompanying spreading depression (SD) were generated by topical potassium chloride application onto the cortical surfaces or by intracortical electrophoretic injection of potassium ions at fixed intervals. Time between waves initiated by topical application gradually increased as did avoidance responding. Avoidance responding was independent of the exact interhemispheric phase relationship of the slow potential waves. With electrophoretic SD generation, avoidance was phasically impaired mainly when the wave passed the motor cortex. Recovery in the interwave intervals was inversely related to injection rate, suggesting an additional cumulative metabolic effect. Thus, both phasic and cumulative SD processes interact to determine avoidance performance. (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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