Motion of myosin filaments due to interaction of the two-headed myosin crossbridge with two actin filaments
- 1 April 1984
- journal article
- research article
- Published by Springer Nature in Journal of Muscle Research and Cell Motility
- Vol. 5 (2) , 117-129
- https://doi.org/10.1007/bf00712151
Abstract
A model of a two-headed myosin crossbridge, whose motion is realized by alternate stepping of its two heads on two actin filaments, is proposed. The geometrical possibility of such crossbridge stepping in contracting skeletal muscle is shown, provided that a free myosin head can bind to an actin filament ata right angle and the attached one can tilt to a greater angle than 45°. Motion of a myosin-like protein along actin filaments in Characean alga cells can proceed by a similar mechanism.This publication has 28 references indexed in Scilit:
- Arrangement of cross-bridges in insect flight muscle in rigorJournal of Molecular Biology, 1981
- Heavy meromyosin cross-links thin filaments in striated muscle myofibrilsNature, 1981
- A new model for the geometry of the binding of myosin crossbridges to muscle thin filamentsJournal of Molecular Biology, 1981
- Cross-linking of actin filaments by heavy meromyosinJournal of Molecular Biology, 1979
- Shape and flexibility of the myosin moleculeJournal of Molecular Biology, 1978
- Generation of force by single-headed myosinJournal of Molecular Biology, 1978
- Substructure of the myosin molecule: III. Preparation of single-headed derivatives of myosinJournal of Molecular Biology, 1973
- Three-dimensional reconstruction of F-actin, thin filaments and decorated thin filamentsJournal of Molecular Biology, 1970
- Ultrastructure of insect flight muscleJournal of Molecular Biology, 1968
- An X-ray and light-diffraction study of the filament lattice of striated muscle in the living state and in rigorJournal of Molecular Biology, 1963