Chronon and the Problem of Anticipation (On two family cases of diabetes)

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Abstract
The Authors analyze the phenomenon whereby, in progressing from generation to generation, a hereditary disease may appear at an earlier, equal or later age (anticipation, repetition or posticipation, respectively). They believe that this represents the phenotypic effect of a temporal dimension of the gene, the “chronon”, which may reveal stability, plus-variance or minus-variance according to the standard genetic models. This interpretation provides an explanation of two family cases of diabetes mellitus, respectively exhibiting anticipation and posticipation, and repetition.

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