THROMBO-EMBOLIC PHENOMENA IN SEVERE ASTHMA - USE OF HEPARIN FOR PREVENTION AND TREATMENT IN PATIENTS RECEIVING ACTH OR GLUCO-STEROIDS

  • 1 January 1963
    • journal article
    • research article
    • Vol. 98  (1) , 27-+
Abstract
Coagulation times and protamine titration values for heparin are apt to be lower than average in patients with allergic disease, particularly asthma. Prolonged high dosage of gluco-corti-coids, either endogenous or exogenous, depresses mast cell function and heparin production. Thrombo-embolic phenomena occur frequently in severe cases of asthma so treated, particularly if predisposing vascular disease is present. Heparin can be used to treat and prevent these complications.