Preparation of N-protected α-amino alcohols by acetoxyborohydride reduction of N-protected α-amino acid esters
- 1 January 1990
- journal article
- Published by Institute of Organic Chemistry & Biochemistry in Collection of Czechoslovak Chemical Communications
- Vol. 55 (3) , 761-765
- https://doi.org/10.1135/cccc19900761
Abstract
N-Protected α-amino alcohols were prepared by reduction of N-protected α-amino acid esters by sodium acetoxyborohydride in dioxane at elevated temperature. The reductions proceed with excellent yields and without racemisation. Reduction of the carbamate protecting groups was not observed.Keywords
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