Therapeutic efficacy of granulocyte colony stimulating factor against rat cecal ligation and puncture model

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Abstract
To identify the therapeutic efficacy of granulocyte colony stimulating factor (G‐CSF) in severe sepsis, we examined its effect on the mortality and pathological changes in vital organs using the rat lethal sepsis model. Rats were given 15 μg of recom‐binant human (rh)G‐CSF after the onset of peritonitis brought about by cecal ligation and puncture. The mortality rate after 72 h was significantly decreased by administration of 15 μg of rhG‐CSF (p < 0.001). In addition, the administration of rhG‐CSF induced an improvement in liver and renal functions. It also produced marked pathological improvement in the lungs. These results strongly indicated that administration of rhG‐CSF, even after the onset of sepsis, was effective in decreasing the mortality from peritonitis‐induced multiple organ failure, and this finding was clearly useful in the clinical treatment of such sepsis‐induced critical illness.

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