Activation of hypolipidaemic drugs to acyl-coenzyme A thioesters

31 October 1986

journal article
research article
Published by Portland Press Ltd. in Biochemical Journal

Vol. 239 (3) , 781-784
https://doi.org/10.1042/bj2390781

Abstract

Compounds possessing the characteristics of CoA thioesters of the hypolipidaemic peroxisome proliferators clofibric acid, nafenopin and ciprofibrate were formed on incubation of the drugs with rat liver microsomal fractions, ATP and CoA. The reactivity of the drugs correlated with their pharmacological potency. It is proposed that the active species of these compounds are their acyl-CoA thioesters.

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