RELATION OF HVH-II TO CARCINOMA OF THE CERVIX

  • 1 January 1979
    • journal article
    • research article
    • Vol. 53  (5) , 553-558
Abstract
An animal [rat] model is described that demonstrates the development of varying degrees of basal cell hyperplasia, metaplasia and dysplasia following cervicovaginal herpesvirus hominis type II (HVH-II) infection. Although the study spanned a period of 30 mo., the equivalent of 60 human yr, there was no evidence of anaplasia. The role of HVH-II as an initiator in the multistep process leading to cervical carcinoma is discussed.