Monooctanoin perfusion treatment of intrahepatic calculi.

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Abstract
Patients (17) who had intrahepatic calculi underwent perfusion with monooctanoin. While 5 patients responded with a decrease in size or number of calculi, only 1 had a complete response; 12 showed no response; and 1 died during the perfusion (however, the perfusion was not believed to have contributed to the death). Of the 17 patients, 5 required further treatment by a combination of basket extraction, oral administration of chenodeoxycholic acid or surgery. The lack of response to monooctanoin perfusion was in part due to calculus composition. Because of the poor response to this treatment and the prolonged hospitalization generally required, monooctanoin is not recommended for dissolution of intrahepatic calculi.