The effect of sulphur mustard on glutathione levels in rat lung slices and the influence of treatment with arylthiols and cysteine esters

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Abstract
1 Sulphur mustard reacts directly with benzenethiols and cysteine esters in aqueous medium. 2 Benzenethiols diffuse into lung slices in short term culture. 3 Treatment of lung slices in short term culture with benzenethiols does not protect cellular glutathione from conjugation with sulphur mustard. 4 Following uptake of cysteine ester into lung slices cysteine is elevated but this does not protect cellular glutathione from sulphur mustard.