A possible role for cell proliferation in potassium bromate (KBrO3) carcinogenesis
- 1 August 1993
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 119 (8) , 463-469
- https://doi.org/10.1007/bf01215926
Abstract
Accumulation of α2u and induction of cell proliferation were examined in kidneys of rats exposed to KBrO3, KBr or NaBrO3 in their drinking water. Hyaline droplets observed after KBrO3 or NaBrO3 administration to male rats were specifically immunostained for α2u. Increases in cell proliferation were found in the proximal tubules of male rats given KBrO3 or NaBrO3 but not KBr for 2, 4, and 8 weeks. No such change was evident in KBrO3-treated female rats or the distal tubules of any treated animal. The concordance between hyaline droplet accumulation and increased cell turnover suggests that KBrO3- and NaBrO3-induced cell replication in kidneys of male rats may result from α2u nephropathy. Considering the fact that KBrO3 has genotoxic potential involving oxidative stress, we hypothesize that the induced cell proliferation might predominantly play an additive role in its carcinogenesis. Furthermore, the present data, showing similar effects of NaBrO3 on the rat kidney, are of direct significance to its risk assessment.Keywords
This publication has 35 references indexed in Scilit:
- Cell proliferation induced in the kidneys and livers of rats and mice by short term exposure to the carcinogen p-dichlorobenzeneArchives of Toxicology, 1992
- Toxicity and carcinogenicity of potassium bromate--a new renal carcinogen.Environmental Health Perspectives, 1990
- Elevated proliferation of proximal tubule cells and localization of accumulated α2u-globulin in F344 rats during chronic exposure to unleaded gasoline or 2,2,4-trimethylpentaneToxicology and Applied Pharmacology, 1989
- Involvement of reversible binding to α2u-globulin in 1,4-dichlorobenzene-induced nephrotoxicityToxicology and Applied Pharmacology, 1989
- 2,2,4-Trimethylpentane-induced nephrotoxicityToxicology and Applied Pharmacology, 1987
- 2,2,4-Trimethylpentane-induced nephrotoxicityToxicology and Applied Pharmacology, 1987
- Histopathology and Cell Proliferation Induced by 2,2,4-Trimethylpentane in the Male Rat KidneyToxicologic Pathology, 1986
- Assessment of the genotoxic potential of unleaded gasoline and 2,2,4-trimethylpentane in human lymphoblasts in vitroToxicology and Applied Pharmacology, 1986
- Long-term toxicity and carcinogenicity studies of the bread improver potassium bromate 1. Studies in ratsFood and Cosmetics Toxicology, 1979
- Toxicity of home permanent waving and neutralizer solutionsFood and Cosmetics Toxicology, 1965