New XLMR syndrome with characteristic face, hypogenitalism, congenital hypotonia and pachygyria

Abstract
A previously unreported X‐linked MCA/MR syndrome is described in 4 members of a large family. Phenotypic manifestations include mental retardation, microcephaly, failure to thrive, severe congenital hypotonia, characteristic face, hypogenitalism, pachygyria. This appears to be an X‐linked dominant trait with decreased penetrance and expressivity in carrier females.

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