This paper describes a series of experiments in which guinea-pigs were inoculated intramuscularly with a strain of fixed-virus rabies, and their wounds treated, after intervals of varying duration, with different viricidal substances. The authors found that cauterization with fuming nitric acid gave no greater protection against the development of rabies than did irrigation with a 20% soap-solution; a cationic detergent, Zephiran, was found to be the treatment of choice for wounds artificially contaminated with rabies virus.