Ruthenium Complex-Catalyzed anti-Markovnikov Hydration of Terminal Alkynes
- 3 February 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 3 (5) , 735-737
- https://doi.org/10.1021/ol0003937
Abstract
Highly regioselective, efficient, and substituent-tolerant anti-Markovnikov hydration of terminal alkynes occurs to give n-aldehyde by use of a catalytic amount of easily available cyclopentadienylruthenium complexes bearing appropriate bidentate or monodentate phosphine ligands. Typically, RuCpCl(dppm) (1 mol %) catalyzes the addition of water to 1-hexyne at 100 °C to give hexanal in 95% yield: 2-hexanone is not detected at all.Keywords
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