Bioavailability of Oral Physostigmine

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Abstract
To the Editor: With the growing interest in the use of oral physostigmine for Alzheimer's disease,1 2 3 it is important to know the proportion of the dose reaching the circulation, since differences in response may be due in part to differences in bioavailability.Three male volunteers (Table 1) received 2 or 3 mg of oral physostigmine salicylate in water. Blood samples were drawn into heparinized tubes containing neostigmine bromide (50 μg for each milliliter of blood) before the dose and at 10-minute intervals thereafter. On a separate occasion Subject 1 was given an intravenous infusion of 1.2 mg of physostigmine salicylate . . .

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