Hemoglobin C Disease

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Abstract
1. The cases of four Negro patients with splenomegaly and targeting of the red cells are reported. 2. Electrophoretic analysis of the hemoglobin in these cases revealed type C hemoglobin exclusively. 3. An analysis of the genetic, clinical, and hematologic manifestations was made. 4. For convenience, the name hemoglobin C disease has been given to the mild hemolytic syndrome observed in these patients. 5. Electrophoretic recognition of hemoglobin C by filter paper and Tiselius technics is illustrated. 6. Differential diagnosis is discussed with special attention directed to the mild form of Mediterranean anemia.