Effects of auranofin on leukotriene production and leukotriene stimulated neutrophil function
- 1 December 1984
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 15 (5-6) , 551-555
- https://doi.org/10.1007/bf01966773
Abstract
Arachidonic acid is metabolized in neutrophils by lipoxygenase to leukotrienes, which are suggested to play a central role in inflammation. The antirheumatic drug auranofin (4 μg/ml) was found not to inhibit neutrophil production of the lipoxygenase products 5-HETE, 15-HETE and LTB4,in vitro when stimulated with the calcium ionophore A23187. Auranofin, however, modulated neutrophil aggregation, enzyme release and chemotaxis induced by LTB4. The results suggest that auranofin may exert some of its antirheumatic effects through affecting neutrophil responses to leukotrienes.This publication has 37 references indexed in Scilit:
- Leukotriene‐induced neutrophil aggregation in vitroFEBS Letters, 1982
- Leukotriene B4 is a complete secretagogue in human neutrophils: A kinetic analysisBiochemical and Biophysical Research Communications, 1982
- Stimulation of human leukocyte degranulation by leukotriene B4 and its ω‐oxidized metabolitesFEBS Letters, 1981
- Leukotriene B4 — a stereospecific stimulator for release of lysosomal enzymes from neutrophilsFEBS Letters, 1981
- Identification and biological activity of novel ω‐oxidized metabolites of leukotriene B4 from human leukocytesFEBS Letters, 1981
- Transformation of 15‐hydroperoxy‐5,9,11,13‐eicosatetraenoic acid into novel leukotrienesFEBS Letters, 1981
- Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.Journal of Clinical Investigation, 1980
- Inhibition of rabbit neutrophil lysosomal enzyme secretion, non-stimulated and chemotactic factor stimulated locomotion by nordihydroguaiaretic acidLife Sciences, 1980
- Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytesNature, 1980
- The inhibitory effects of BW 755C on arachidonic acid metabolism in human polymorphonuclear leukocytesFEBS Letters, 1980