Evidence for icaADBC -Independent Biofilm Development Mechanism in Methicillin-Resistant Staphylococcus aureus Clinical Isolates
Open Access
- 1 April 2005
- journal article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 43 (4) , 1973-1976
- https://doi.org/10.1128/jcm.43.4.1973-1976.2005
Abstract
Synthesis of a polysaccharide adhesin by icaADBC -encoded enzymes is currently the best-understood mechanism of staphylococcal biofilm development. In four methicillin-resistant Staphylococcus aureus isolates, environmental activation of icaADBC did not always correlate with increased biofilm production. Moreover, glucose-mediated biofilm development in these isolates was icaADBC independent. Apparently, an environmentally regulated, ica -independent mechanism(s) of biofilm development exists in S. aureus clinical isolates.Keywords
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