The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer
- 6 February 2008
- journal article
- review article
- Published by Springer Nature in Cancer and Metastasis Reviews
- Vol. 27 (2) , 169-178
- https://doi.org/10.1007/s10555-008-9125-z
Abstract
Although the aberrant actions of protein kinases have long been known to contribute to tumor promotion and carcinogenesis, roles for protein phosphatases in the development of human cancer have only emerged in the last decade. In this review, we discuss the data obtained from studies examining the biological and pathological roles of a serine/threonine protein phosphatase, PP5, which suggest that PP5 is a potentially important regulator of both hormone- and stress-induced signaling networks that enable a cell to respond appropriately to genomic stress.Keywords
This publication has 80 references indexed in Scilit:
- Mice Lacking Protein Phosphatase 5 Are Defective in Ataxia Telangiectasia Mutated (ATM)-mediated Cell Cycle ArrestPublished by Elsevier ,2007
- DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosisJournal of Zhejiang University-SCIENCE B, 2007
- Regulation of the Raf–MEK–ERK pathway by protein phosphatase 5Nature Cell Biology, 2006
- Ser/Thr Protein Phosphatase 5 Inactivates Hypoxia-induced Activation of an Apoptosis Signal-regulating Kinase 1/MKK-4/JNK Signaling CascadeJournal of Biological Chemistry, 2004
- Requirement of protein phosphatase 5 in DNA-damage-induced ATM activationGenes & Development, 2004
- A p53 Amino-Terminal Nuclear Export Signal Inhibited by DNA Damage-Induced PhosphorylationScience, 2001
- Cancer Cell CyclesScience, 1996
- The Tetratricopeptide Repeat Domain of Protein Phosphatase 5 Mediates Binding to Glucocorticoid Receptor Heterocomplexes and Acts as a Dominant Negative MutantJournal of Biological Chemistry, 1996
- Chromosomal Localization and 5′ Sequence of the Human Protein Serine/Threonine Phosphatase 5′ GeneBiochemical and Biophysical Research Communications, 1996
- Protein serine/threonine phosphatases; an expanding familyFEBS Letters, 1990