Granisetron prevents nausea and vomiting during spinal anaesthesia for caesarean section

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Abstract
Background: Nausea and vomiting during spinal anaesthesia for caesarean section are common and unpleasant complications. This study was undertaken to evaluate the efficacy of granisetron, a selective 5‐hydroxytryptamine type 3 receptor antagonist, for prophylactic treatment of nausea and vomiting in parturients undergoing nonemergent caesarean section under spinal anaesthesia. Methods: In a randomized, double‐blind, placebo‐controlled trial, 100 patients, 21–38 years, received either placebo (saline) or granisetron at 3 different doses (20 μg · kg‐1, 40 μg · kg‐1 or 80 μg · kg‐1) (n=25 for each) intravenously immediately after clamping of the foetal umbilical cord. Nausea, vomiting and safety assessments were performed during spinal anaesthesia for caesarean section. Results: The treatment groups were similar with regard to maternal characteristics and operative management. The incidence of nausea and vomiting was 64%, 52%, 14% and 12% after administration of placebo and granisetron in a dose of 20 μg · kg‐1, 40 μg · kg‐1 and 80 μg · kg‐1, respectively (P‐1 is effective for preventing nausea and vomiting during spinal anaesthesia for caesarean section. © Acta Anaesthesiologiat Scandinavica 42 (1998)