Mirtazapine: pharmacology in relation to adverse effects
- 1 September 1997
- journal article
- Published by Wiley in Acta Psychiatrica Scandinavica
- Vol. 96 (s391) , 31-37
- https://doi.org/10.1111/j.1600-0447.1997.tb05956.x
Abstract
Mirtazapine is a new antidepressant that falls into the general class of receptor-blocking drugs rather than being an uptake or enzyme inhibitor. It can be described as a noradrenergic and specific serotonergic antidepressant (NaSSA). The unique pharmacology of mirtazapine means that it has a very different side effect profile from the tricyclic antidcpressants, producing less α1 adrenergic and musearinic blockade. and the selective serotonin reuptake inhibitors (SSRIs) and the serotonin-noradrenaline reuptake inhibitors (SNRls), causing much less nausea and sexual dysfunction by virtue of its blockade of 5-HT2 and 5-HT3 receptors.Keywords
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