HISTOPATHOLOGY OF GOLDMANN-FAVRE SYNDROME OBTAINED BY FULL-THICKNESS EYE-WALL BIOPSY

  • 1 January 1977
    • journal article
    • research article
    • Vol. 9  (4) , 479-484
Abstract
The 1st histopathologic specimen from the eye of a patient with Goldmann-Favre syndrome was obtained by full-thickness eye-wall biopsy. Diagnosis was established by an early history of night blindness, characteristic clinical features including atypical pigmentary retinopathy, peripheral retinoschisis, opaque sclerotic-appearing peripheral retinal vessels, vitreous changes including liquefaction and condensed vitreous bands and a non-detectable electroretinogram (ERG). Histopathologic changes from a 4 mm peripheral area included diffuse degenerative changes involving predominantly the sensory retinal layers with a relatively normal pigment epithelium and choroid. Vascular changes included thickened retinal vessel basement membranes and areas of vascular occlusion. These findings were compatible with a primary photoreceptor involvement in addition to a vascular component. A thick preretinal membrane of glial tissue was an additional finding.

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