Pseudomonas aeruginosa Pyocyanin Is Critical for Lung Infection in Mice
Top Cited Papers
Open Access
- 1 July 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (7) , 4275-4278
- https://doi.org/10.1128/iai.72.7.4275-4278.2004
Abstract
Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.Keywords
This publication has 28 references indexed in Scilit:
- Human targets of Pseudomonas aeruginosa pyocyaninProceedings of the National Academy of Sciences, 2003
- ThePseudomonassecretory product pyocyanin inhibits catalase activity in human lung epithelial cellsAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2003
- Use of the Galleria mellonella Caterpillar as a Model Host To Study the Role of the Type III Secretion System in Pseudomonas aeruginosa PathogenesisInfection and Immunity, 2003
- Functions Required for Extracellular Quinolone Signaling by Pseudomonas aeruginosaJournal of Bacteriology, 2002
- Pyocyanin induces oxidative stress in human endothelial cells and modulates the glutathione redox cycleFree Radical Biology & Medicine, 2002
- Induction of Neutrophil Apoptosis by thePseudomonas aeruginosaExotoxin Pyocyanin: A Potential Mechanism of Persistent InfectionThe Journal of Immunology, 2002
- A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanismProceedings of the National Academy of Sciences, 2001
- Functional Analysis of Genes for Biosynthesis of Pyocyanin and Phenazine-1-Carboxamide from Pseudomonas aeruginosa PAO1Journal of Bacteriology, 2001
- Phenazine Pigments in Pseudomonas aeruginosa InfectionPublished by Springer Nature ,1993
- Biological Effects of Pseudomonas aeruginosa Phenazine PigmentsPublished by S. Karger AG ,1986