Glimpses of a Tiny RNA World
- 26 October 2001
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 294 (5543) , 797-799
- https://doi.org/10.1126/science.1066315
Abstract
Naturally tiny regulatory RNAs of about 22 nucleotides were first identified from Caenorhabditis elegans genetics. Artificially induced RNAs of this size are also an intermediate in RNA interference, and both such RNAs use a common biochemical processing pathway. Now three groups have shown that there is an entire world of tiny RNAs that had almost escaped detection until now. These tiny RNAs are likely to regulate the translation of other mRNAs during development and, like the intermediates in RNAi, may be subject to amplification and systemic spread.Keywords
This publication has 19 references indexed in Scilit:
- An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegansScience, 2001
- An Extensive Class of Small RNAs in Caenorhabditis elegansScience, 2001
- Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAiScience, 2001
- A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of thelet-7Small Temporal RNAScience, 2001
- Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental TimingCell, 2001
- AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animalsProceedings of the National Academy of Sciences, 2000
- A Species of Small Antisense RNA in Posttranscriptional Gene Silencing in PlantsScience, 1999
- The 3′-untranslated region of CaMKIIα is a cis-acting signal for the localization and translation of mRNA in dendritesProceedings of the National Academy of Sciences, 1996
- The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14Cell, 1993
- Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegansCell, 1993