Synthetic Studies on Highly Modified Nucleosides Directed towards Creation of Anti-HIV Agents
Open Access
- 1 January 1993
- journal article
- abstracts
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 113 (4) , 285-306
- https://doi.org/10.1248/yakushi1947.113.4_285
Abstract
Recent studies on the synthesis of highly modified nucleosides, especially carbocyclic nucleosides, aiming at creating anti-HIV agents have been reviewed. The review includes new methods for the synthesis of carbocyclic C-nucleosides and carbocyclic N-nucleosides including carbocyclic oxetanocin and its analogues developed in our laboratory. Among the carbocyclic nucleosides synthesized, 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine (BCA) showed significant anti-HIV activity.Keywords
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