Spectrophotometric determination of amodiaquine hydrochloride in pharmaceutical dosage forms

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Abstract
A simple, sensitive and selective spectrophotometric method has been developed for the determination of amodiaquine hydrochloride and its dosage forms, which is based on a colour reaction with chloramine-T in the pH range 7.4–8.0. The chromogen, after extraction into chloroform, is measured at 442 nm. Beer's law is obeyed in the concentration range 0–200 µg ml–1 of amodiaquine hydrochloride. The identity of the chromogen is deduced from the infrared and nuclear magnetic resonance spectral data.

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