Biomimetic chemistry of camptothecin: involvement of isovincoside lactam (Strictosamide)
- 1 January 1974
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 22,p. 928
- https://doi.org/10.1039/c39740000928
Abstract
The indole αβ-bond of isovincoside lactam (strictosamide)(2a) is cleaved much more rapidly by either NaIO4 or oxygen–KBuOt than the corresponding bond of vincoside lactam (2b), which may be significant in the biosynthetic preference of (2a) over (2b) in the biosynthesis of camptothecin (1).Keywords
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