SYNTHESIS OF VIRUS-SPECIFIC PROTEINS IN TICK-BORNE ENCEPHALITIS VIRUS-INFECTED PIG EMBRYO KIDNEY-CELLS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 24  (5) , 305-+
Abstract
Purified virions of tick-borne encephalitis (TBE) virus contain 3 proteins, V1, V2 and V3, with MW of 8000, 13,000 and 53,000 daltons, respectively. Seven virus-specific polypeptides were revealed in TBE-virus-infected continuous pig embryo kidney cells: p93-96, p79, p69, p53, p47, p16 and p13 (pN designating polypeptide with a MW of N .times. 1000 daltons). Proteins p93-96, p69, p53, p47 and p13 corresponded by their MW to proteins NV5, NV4, V3 and V2 (NV1 1/2) of mosquito-borne flaviviruses. Protein p79, designated NV4 1/2, and protein p16 (the only virus-specific protein inhibited by hypertonic NaCl concentrations), had no analogs among proteins of mosquito-borne flaviviruses. The possibility of a cellular origin of protein p47 (NV3) is discussed.