Acute Hemolytic Anemia Complicating Viral Hepatitis in Patients with Glucose-6-Phosphate Dehydrogenase Deficiency

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Abstract
Although shortened erythrocyte survival can frequently be demonstrated, severe anemia has rarely been noted during acute viral hepatitis (1-3). In the few reported cases of hemolytic anemia complicating hepatitis no mechanism explaining the increased red cell destruction has been established (4-6). Increased splenic pulp pressure (7) or elevated gamma globulin levels (8), observed in viral hepatitis, could not be related to the development of hemolysis (2, 4, 6). Burka, Weaver, and Marks (9) most recently suggested that erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency may predispose to the development of hemolytic anemia during viral hepatitis. This report deals with three patients who

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