The Effects of Ovarian Hormones on Glucose and Fatty Acid Oxidation during Exercise in Female Ovariectomized Rats

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Abstract
The effects of ovarian hormones on glucose and fatty acid oxidation during exercise were investigated in adult female ovariectomized rats. Rats subdivided into 3 groups received intraperitoneal injections of hormones or sesame oil for 8 days. Estrogen (E) treated rats received 17-β estradiol in daily doses of 2 μg. Estrogen and progesterone treated rats (EP) received 17-β estradiol in daily doses of 2 μg and 2 mg, respectively. Control rats (S) received sesame oil alone. After an overnight fast, rats ran at the speed of 25 m · min-1 for 60 min. [U-14C]glucose or [1-14C]palmitate was injected into rats at 5 min of exercise and before 10 min of exercise, respectively. Expired 14CO2 was collected using bottomless chamber on a treadmill belt. No significant differences were found in mean blood glucose, lactate and plasma free fatty acid concentrations after the exercise. Until the end of the exercise 34.7±2.6 (E, n=5), 40.8±2.9 (EP, n=5) and 43.7± 3.5% (S, n=6) (mean±SE) of 14C which was injected as 14C-glucose was recovered as 14CO2. During 60 min of the exercise 27.5±1.0 (E, n=7), 19.8±2.7 (EP, n=6) and 25.0±1.9% (S, n=6) of 14C which was injected as 14C-palmitate was recovered as 14CO2. A significant difference was found in this rate between E and EP (P < 0.05). It was concluded that estrogen treatment stimulated fatty acid oxidation compared with the estrogen plus progesterone treatment and tended to inhibit glucose oxidation during prolonged exercise.

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