Glycine-Rich Analogues ofCucurbita maximaTrypsin Inhibitor (CMTI-III) Substituted by Valine in Position 27 Display Relatively Low Antitrypsin Activity
- 1 January 1993
- journal article
- Published by Walter de Gruyter GmbH in Biological Chemistry Hoppe-Seyler
- Vol. 374 (7-12) , 851-854
- https://doi.org/10.1515/bchm3.1993.374.7-12.851
Abstract
Five new analogues of the trypsin inhibitor CMTI-III were synthesized by the solid-phase method. All analogues containing a valine residue in position 27 and glycine residues in some or all of the positions 9, 11, 14, 17, 19, 29 as well as in two cases a norleucine residue in position 8 displayed association equilibrium constants by 6-7 orders of magnitude lower than the native CMTI-III inhibitor.Keywords
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