Influence of Tetrazolium Salts on Human Pseudocholinesterase.

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Abstract
Six tetrazolium salts were tested for anticholinesterase activity using a manometric technique. All of the tetrazolium compounds inhibited cholinesterase, with tetrazolium blue and its nitro derivative demonstrating greatest inhibitory effects, neotetrazolium and its nitro derivative showing more moderate effects, and triphenytetrazolium chloride and 2-p-iodo-3-p-nitro-5-phrnyl tetrazolium chloride producting least inhibition. The ditetrazoliums, containing a greater number of tertiary amine groups than the monotetrazolimus, are more potent inhibitors of cholinesterase. Neurotoxic effects of tetrazolium salts may be due to interference with neural enzyme systems.

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