STUDIES OF SKELETAL TRACER KINETICS .2. EVALUATION OF A 5-COMPARTMENT MODEL OF [FLUORIDE-F-18 KINETICS IN RATS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 20  (11) , 1150-1157
Abstract
A 5-compartment model of [18F]fluoride kinetics in rats was evaluated. The initial fluoride distribution was similar to that of [77Br]bromide, a known extracellular fluid (ECF) tracer, in agreement with the hypothesis underlying the model, and the measured uptake rate in rat bones compared well with the digital computer solution. Simpler models did not give a better fit. In dead rats fluoride movement was found within the skeleton, presumably from bone ECF to bone substance, although not as rapidly as predicted or found in the live animals. Evaluation of the rate constants permitted estimates to be made of cardiac output, skeletal blood flow and bone ECF volume, all in accord with independent measurements. Apparently skeletal blood flow at rest is a constant fraction of body weight, and probably subserves a hematopoietic and a mineralization function.