Effects of Glucagon on Free Fatty Acid Metabolism in Humans*
- 1 February 1991
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 72 (2) , 308-315
- https://doi.org/10.1210/jcem-72-2-308
Abstract
To determine whether physiological changes in plasma glucagon concentrations are important in regulating basal adipose tissue lipolysis, FFA flux ([l–14C]palmitate) was measured in response to increases and decreases in plasma glucagon. Eight volunteers with insulin-dependent diabetes mellitus (IDDM) and nine healthy nondiabetic volunteers were studied using the pancreatic clamp technique to control plasma insulin, GH, and glucagon concentrations at desired levels. Palmitate flux at the chosen euglucagonemic hormone infusion rates was similar to baseline values (1.73 ± 0.12 vs. 1.75 ± 0.23 and 1.35 ± 0.18 vs. 1.35 ± 0.16 μmol/kg·min, respectively, in IDDM and nondiabetic subjects). No significant changes in palmitate flux occurred in response to glucagon withdrawal or mild (non-diabetic volunteers) or high physiological (IDDM volunteers) hyperglucagonemia. Thus, undei conditions of normal FFA availability, changes in plasma glacagon concentrations within the physiological range have little or no effect on adipose tissue lipolysis.Keywords
This publication has 0 references indexed in Scilit: