MECHANISM OF THE VASCULAR ACTION OF TETRAETHYLAMMONIUM CHLORIDE

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Abstract
Observations in dogs, cat and man suggest that the action of tetraethylammonium chloride on arterial pressure is compounded of at least 3 factors autonomic blockade reducing or eliminating tonic vasomotor impulses which lowers arterial pressure; stimulation of the liver, to liberate a noradrenalin-like substance which, acting on a more than normally sensitive vascular tree, raises blood pressure; and less importantly, liberation of adrenalin from the adrenal glands. The net effect on arterial pressure is the resultant of the forces tending to lower opposed by those tending to elevate it.__I. H. Page. cise any narcotic action itself. In the discussion the possibility is suggested that the actions described are general characteristics of narcotics. Lammers claims that the deviating behavior of chloral hydrate supports the theory that the curare-action is due to the checking effect of the action of acetylcholine.