Survival of Thermally Injured Rats Infused with Saline, Polyvinylpyrrolidone, Dextran and Oxypolygelatin

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Abstract
Ten-day survival percentages are recorded for severely burned rats, infused with saline and several macromolecular solns. and for the simultaneous untreated controls. Hypertonic saline solns. were more effective in promoting survival than isotonic saline solns. Effectiveness of the macromol. solns. in promoting survival decreased as the concn. of these substances was increased. Due to the specific allergic reaction of rats to dextran, the relative effectiveness of this plasma expander could not be ascertained. Hematocrit data recorded in terms of % of initial values are given for several animals in all groups. Hypertonic saline solns. tend to maintain a cell-plasma ratio more nearly approaching the initial than isotonic solns. Increased hemodilution followed infusions of the higher concns. of macromol. substances. Hemodilution in general cannot be directly correlated with survival; however, the lowest hemodilution values were found, except for saline, in those groups having the lowest survival percentage.