Elevated Expression of T-Antigen in Skin Fibroblasts from Individuals with Cytogenetic Anomalies Infected in Vitro with Simian or Human Papovaviruses

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Abstract
Human skin fibroblasts were infected with human papovavirus (BK type) or simian papovavirus 40 (SV40) at multiplicities of infection which induced similar frequencies of T-antigen-containing cells at 72 hr after infection. Both viruses exhibited a higher rate of T-antigen expression in cells from genetically abnormal individuals with Fanconi anemia, Turner's syndrome, or Klinefelter's syndrome than in cells from normal individuals.