Genetic epidemiology of 'neurotic' disorders

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Abstract
We review the literature on the genetic epidemiology of four 'neurotic' disorders along with the personality trait of neuroticism.Unipolar depression, phobic disorders, panic disorder, neuroticism, and, to a lesser extent, generalized anxiety disorder are familial. The familiality of these disorders and neuroticism appears to be due to genetic factors, particularly for unipolar depression and neuroticism. Despite substantial interest in the molecular genetics of unipolar depression, panic disorder, and neuroticism, no genes have as yet been definitively identified.

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