TAK1-mediated transcriptional activation of CD28-responsive element and AP-1-binding site within the IL-2 promoter in Jurkat T cells
- 9 November 2005
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (29) , 6641-6646
- https://doi.org/10.1016/j.febslet.2005.10.059
Abstract
We focused on the functional involvement of transforming growth factor-beta-activated kinase 1 (TAK1) in transcriptional regulation of interleukin-2 (IL-2) in T cells. Costimulation of Jurkat cells with 12-O-tetradecanoylphorbol-13-acetate and A23187 leads to a rapid phosphorylation of TAK1 and TAK1-binding protein 1 (TAB1), critical for TAK1 activation. A specific inhibitor of TAK1 blocked production of IL-2. In addition, overexpression of TAK1 and TAB1 induced secretion of IL-2. CD28-responsive element/activator protein-1-binding site (RE/AP) within the IL-2 promoter was a functional target for TAK1. The RE/AP-driven transcription was regulated by TAK1-mediated activation of the c-Jun NH2-terminal kinase, p38 and IkappaB kinase. These results indicate that TAK1 plays a critical role in T cell activation by controlling production of IL-2.Keywords
This publication has 29 references indexed in Scilit:
- Critical Roles of Threonine 187 Phosphorylation in Cellular Stress-induced Rapid and Transient Activation of Transforming Growth Factor-β-activated Kinase 1 (TAK1) in a Signaling Complex Containing TAK1-binding Protein TAB1 and TAB2Journal of Biological Chemistry, 2005
- MALT1/Paracaspase Is a Signaling Component Downstream of CARMA1 and Mediates T Cell Receptor-induced NF-κB ActivationJournal of Biological Chemistry, 2004
- Nuclear Factor of Activated T Cells c Is a Target of p38 Mitogen-Activated Protein Kinase in T CellsMolecular and Cellular Biology, 2003
- A Resorcylic Acid Lactone, 5Z-7-Oxozeaenol, Prevents Inflammation by Inhibiting the Catalytic Activity of TAK1 MAPK Kinase KinaseJournal of Biological Chemistry, 2003
- TAK1 is Critical for IκB Kinase-mediated Activation of the NF-κB PathwayJournal of Molecular Biology, 2003
- TAK1–TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-κB signaling pathwaysBiochemical and Biophysical Research Communications, 2002
- MEKK2 Is Required for T-cell Receptor Signals in JNK Activation and Interleukin-2 Gene ExpressionPublished by Elsevier ,2001
- Mixed-Lineage Kinase 3 Delivers CD3/CD28-Derived Signals into the IκB Kinase ComplexMolecular and Cellular Biology, 2000
- TAK1 mediates an activation signal from toll‐like receptor(s) to nuclear factor‐κB in lipopolysaccharide‐stimulated macrophagesFEBS Letters, 2000
- Activation of transcription factor NF-κB in experimental glomerulonephritis in ratsPublished by Elsevier ,1999