The basement membrane of the atrophic kidney tubule

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Abstract
In a light microscopic and EM study of the rat''s kidney after obstruction of the renal vein or after subtotal nephrectomy the tubular basement membrane changes occurring during the ensuing atrophy of the tubules were examined. Characteristically, they consisted of diffuse widening, focal thickening with vesicular and granular inclusions, circumscribed dissolution, or reduplication of this structure. The tubular basement membrane was formed by both interstitial and tubular cells, although the interstitial cells contributed the greater share to its formation, maintenance and renewal. The thickening of the basement membrane taking place in tubular atrophy must, however, be attributed entirely to the interstitial cells.