Butyrate suppression of position-effect variegation in Drosophila melanogaster
- 1 May 1980
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 178 (2) , 465-469
- https://doi.org/10.1007/bf00270501
Abstract
Summary The strain of Drosophila melanogaster carrying the inversion In(1)w m4, which juxtaposes the normal w + gene to the centromeric heterochromatin, variegates for pigmentation in the eye. This strain was treated with various concentrations of n-butyrate and n-proprionate during the embryonic and larval stages. Concentrations as low as 70mM markedly suppress the variegated eye phenotype. This suggests that non-acetylated histones play a major role in the phenomenon of position-effect variegation.Keywords
This publication has 24 references indexed in Scilit:
- Histone gene deficiencies and position–effect variegation in DrosophilaNature, 1979
- The effect of sodium butyrate on histone modificationCell, 1978
- Sodium butyrate inhibits histone deacetylation in cultured cellsCell, 1978
- A possible role of “inert” heterochromatin in cell differentiation. Action of and competition for “locking” moleculesBiochimie, 1974
- Position effect variegation in the mouseGenetics Research, 1974
- On the relationship between heterochromatization and variegation inDrosophila, with special reference to temperature sensitive periodsGenetics Research, 1967
- THE DEVELOPMENT OF PIGMENT GRANULES IN THE EYES OF WILD TYPE AND MUTANT DROSOPHILA MELANOGASTER The Journal of cell biology, 1966
- ON THE COMPARISON OF SEVERAL MEAN VALUES: AN ALTERNATIVE APPROACHBiometrika, 1951
- The Modification of the Expression of a Position EffectThe American Naturalist, 1949
- The position effect proved by a spontaneous reinversion of theX-chromosome inDrosophila melanogasterJournal of Genetics, 1937