Comparison of the internalization efficiency of LDL and transferrin receptors on L2C guinea pig lymphocytes
- 17 February 1986
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 196 (2) , 242-246
- https://doi.org/10.1016/0014-5793(86)80255-1
Abstract
We demonstrate that L2C lymphocytes have about 10-times more receptors for transferrin (TO than healthy lymphocytes, as has been shown in the case of LDL receptors. The dissociation constant is the same in the two cell types (about 4 × 10−7 M). In contrast to LDL, Tf enters L2C lymphocytes with very rapid kinetics. It is shown by cross-reaction that each receptor is internalized independently of the other.Keywords
This publication has 16 references indexed in Scilit:
- Quantification of endocytosis-derived membrane trafficBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1985
- Role of transferrin, Fe, and transferrin receptors in myeloid leukemia cell growth. Studies with an antitransferrin receptor monoclonal antibody.Journal of Clinical Investigation, 1985
- Characterization of Low Density Lipoprotein Receptors in Freshly Isolated Leukemic Guinea Pig Lymphocytes (L2C)Journal of Receptor Research, 1985
- Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts.The Journal of cell biology, 1982
- Co-clustering and internalization of low-density lipoproteins and α2-macroglobulin in human skin fibroblastsExperimental Cell Research, 1982
- Plasma Lipoproteins of Leukemic Guinea Pigs (L2C) Can Regulate Cholesterol Biosynthesis by Lymphocytes of Normal Guinea PigsEuropean Journal of Biochemistry, 1981
- Inefficient internalization of receptor-bound low density lipoprotein in human carcinoma A-431 cells.The Journal of cell biology, 1981
- Coated pits, coated vesicles, and receptor-mediated endocytosisNature, 1979
- THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUMJournal of Clinical Investigation, 1955
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSAnnals of the New York Academy of Sciences, 1949