11-DEOXYCORTISOL IN AMNIOTIC FLUID: PRENATAL DIAGNOSIS OF CONGENITAL ADRENAL HYPERPLASIA DUE TO 11 β-HYDROXYLASE DEFICIENCY
- 1 March 1980
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 12 (3) , 257-260
- https://doi.org/10.1111/j.1365-2265.1980.tb02708.x
Abstract
The mean control level of 11-deoxycortisol as determined by radioimmunoassay in eighty-one human amniotic fluid samples was 1·20 ± 0·07 ng/ml. Markedly elevated levels were found at term in amniotic fluid of two pregnancies with fetuses affected with 11 β-hydroxylase deficiency, congenital adrenal hyperplasia (135·0 and 64·0 ng/ml respectively) as well as in the maternal serum of one of these cases (28·0 ng/ml). It is suggested that the determination of 11-deoxycortisol in amniotic fluid be a prenatal diagnostic test for 11 β-hydroxylase deficiency congenital adrenal hyperplasia.This publication has 6 references indexed in Scilit:
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- Maternal and amniotic fluid 17α-hydroxyprogesterone levels during pregnancy: Diagnosis of congenital adrenal hyperplasia in uteroAmerican Journal of Obstetrics and Gynecology, 1978
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- RADIOIMMUNOASSAY OF 11-DEOXYCORTISOL IN HUMAN PLASMAActa Endocrinologica, 1974
- Development of Endocrine Function in the Human Placenta and FetusNew England Journal of Medicine, 1969