A reinterpretation of tyramine sympathomimetic effect and tachyphylaxis

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Abstract
In this commentary, the indirect sympathomimetic effect of tyramine and the phenomenon of tyramine tachiphylaxis are reinterpreted in terms of carriermediated excahange processes. Extracellular tyramine would exchange with intraterminal noradrenaline and, upon repeated tyramine administration, with a mixture of noradrenaline and tyramine progressively more enriched in the pharmacologically inactive amine.