Predicting protein structure using only sequence information
- 1 January 1999
- journal article
- research article
- Published by Wiley in Proteins-Structure Function and Bioinformatics
- Vol. 37 (S3) , 121-125
- https://doi.org/10.1002/(sici)1097-0134(1999)37:3+<121::aid-prot16>3.3.co;2-h
Abstract
This paper presents results of blind predictions submitted to the CASP3 protein structure prediction experiment. We made predictions using the SAM-T98 method, an iterative hidden Markov model–based method for constructing protein family profiles. The method is purely sequence-based, using no structural information, and yet was able to predict structures as well as all but five of the structure-based methods in CASP3. Proteins Suppl 1999;3:121–125.Keywords
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