Synthesis of Iodoalkylacylates and Their Use in the preparation ofS-Alkyl Phosphorothiolates
- 1 September 1995
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 25 (18) , 2739-2749
- https://doi.org/10.1080/00397919508011821
Abstract
Synthesis of iodoalkylacylates 3a-f and use of 3 c in the preparation of an oligonucleoside phosphorothiate prodrug analog 5 is described.Keywords
This publication has 15 references indexed in Scilit:
- Prodrugs of Oligonucleotides: The Acyloxyalkyl Esters of Oligodeoxyribonucleoside PhosphorothioatesBioorganic Chemistry, 1995
- Permeability of Ketorolac Acid and Its Ester Analogs (Prodrug) through Human Cadaver SkinJournal of Pharmaceutical Sciences, 1994
- Stereospecific bio-reversibility of dinucleoside S-alkyl phosphorothiolates to dinucleoside phosphorothioatesBioorganic & Medicinal Chemistry Letters, 1994
- Synthesis, Hydrolytic Behavior, and Anti-Hiv Activity of Selected Acyloxyalkyl Esters of Trisodium Phosphonoformate (Foscarnet Sodium)Journal of Pharmaceutical Sciences, 1994
- Equal inhibition of the replication of human immunodeficiency virus in human T-cell culture by ddA BIS(SATE)phosphotriester and 3′-azido-2′,3′-dideoxythymidineBiochemical Pharmacology, 1994
- Synthesis, Oral Bioavailability Determination, and in vitro Evaluation of Prodrugs of the Antiviral Agent 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA)Journal of Medicinal Chemistry, 1994
- Intracellular delivery of nucleoside monophosphates through a reductase-mediated activation processAntiviral Research, 1993
- Novel anticancer prodrugs of butyric acid. 2Journal of Medicinal Chemistry, 1992
- Synthesis of acyloxyalkyl acylphosphonates as potential prodrugs of the antiviral, trisodium phosphonoformate (foscarnet sodium)Tetrahedron Letters, 1989
- Bioreversible phosphate protective groups: Synthesis and stability of model acyloxymethyl phosphatesBioorganic Chemistry, 1984