An Immuno-Cytopathogenic Interaction between Sensitized Leukocytes and Epithelial Cells Carrying a Persistent Noncytocidal Myxovirus Infection

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Abstract
Summary: Experiments in vitro have demonstrated that splenocytes from mice immunized 4 to 5 days previously with mumps virus destroy and/or inhibit the growth of epithelial cells persistently carrying a non-cytocidal mumps virus infection. Because this cytotoxic reaction is immunologically specific and appears to be induced by contact between immune leukocytes and virus antigen associated with target cell plasma membranes, it can be evaluated as a manifestation of the efferent arc of a homograft response to viral infection, and is therefore considered to be a component of cellular immunity.

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