THE INFLUENCE OF GLUCOSE, FRUCTOSE, AND INSULIN ON THE METABOLISM OF LEUKOCYTES OF HEALTHY AND DIABETIC SUBJECTS 12

Open Access
Publisher Website
Google Scholar
Abstract
Leukocytes from healthy individuals produce more lactic acid from glucose than from fructose, and fructose increases the glucose utilization. This difference is abolished by grinding the cells. Leukocytes from diabetic subjects produce more lactic acid from fructose than from glucose. In the healthy subject, insulin had no measured effect on the lactate production of the cell; in the diabetic, it produced a significant increase in lactate formation with glucose but not with fructose. The utilization of glucose was significantly increased by insulin in the diabetic group but not in the control group. Cell injury blocked the hormone effect.