INDUCTION OF GASTRIC-CANCER IN MONKEYS BY N-METHYL-N-NITRO-N-NITROSOGUANIDINE (MNNG)

  • 1 January 1989
    • journal article
    • research article
    • Vol. 36  (2) , 129-133
Abstract
N-methyl-N-nitro-N-nitrosoguanidine (MNNG) was administered to 9 Macaca fascicularis monkeys (7 males and 2 females) through a tube at a dose of 40 mg/kg body weight 3 times a month. Tumors of the pyloric part of the stomach were observed in 2 male monkeys after MNNG doses of 800 and 848 mg/kg body weight, with a latent period of tumor development of 49 and 50 weeks, respectively. Histologically, in one case the tumor was a solid carcinoma, and in the other it had a mixed structure showing alternating solid and signet ring cell carcinoma areas.